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Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro

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Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro

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Título Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro
Autor Bellagamba, Bruno Corrêa
Abreu, Bianca Regina Ribas de
Grivicich, Ivana
Markarian, Carolina Franke
Chem, Eduardo Mainieri
Camassola, Melissa
Nardi, Nance Beyer
Dihl, Rafael Rodrigues
Abstract Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential, trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 1 (Jan./Mar. 2016), p. 129-134
Assunto Cisplatina
Citotoxicidade
Genotoxicidade
[en] Cisplatin
[en] Comet assay
[en] Mesenchymal stem cells
[en] MTT
[en] OVCAR-3 cells
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/147212
Arquivos Descrição Formato
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