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Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil

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Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil

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Título Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil
Autor Maia, Carlos Renato Moreira
Stella, Steffan Frosi
Wagner, Flávia
Pianca, Thiago Gatti
Krieger, Fernanda Valle
Cruz, Luciane Nascimento
Polanczyk, Guilherme Vanoni
Rohde, Luis Augusto Paim
Polanczyk, Carisi Anne
Abstract Objective: To perform a cost-utility analysis on the treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate immediate-release (MPH-IR) in children and adolescents from Brazil. Method: A Markov model was constructed to compare MPH-IR vs. no treatment. A 24-week naturalistic study was conducted to collect transition probabilities and utility data. Effectiveness was expressed as quality-adjusted life-years (QALY), and costs reported in 2014 international dollars (I$). The perspective was the Brazilian Unified Health System as payer, and the time horizon was 6 years. Results: Of 171 patients, 73 provided information at baseline, and 56 at week 24. Considering the MPH-IR monthly cost of I$ 38, the incremental cost-effectiveness ratio (ICER) of treatment was I$ 9,103/QALY for children and I$ 11,883/QALY for adolescents. In two-way sensitivity analysis, considering one Gross National Product per capita (I$ 11,530) as willingness-to-pay, a cost of no-treatment lower than I$ 45/month would render MPH-IR a cost-saving strategy. Discussion: MPH-IR treatment of children and adolescents is cost-effective for ADHD patients from the Brazilian public health system perspective. Both patients and the healthcare system might benefit from such a strategy.
Contido em Revista brasileira de psiquiatria (1999). São Paulo. Vol. 38, n. 1 (jan./mar. 2016), p. 30–38
Assunto Análise custo-eficiência
Metilfenidato
Transtorno do déficit de atenção com hiperatividade
[en] Attention deficit hyperactivity disorder
[en] Cost-utility analysis
[en] Methylphenidate
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/147575
Arquivos Descrição Formato
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