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Determinants of body weight regulation in humans

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Determinants of body weight regulation in humans

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Título Determinants of body weight regulation in humans
Autor Moehlecke, Milene
Canani, Luis Henrique Santos
Silva, Lucas Oliveira Junqueira e
Trindade, Manoel Roberto Maciel
Friedman, Rogério
Leitão, Cristiane Bauermann
Abstract Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have been identified, there is a need to know in more detail their actions as well as their interactions with environmental and psychosocial factors in the development of human obesity. In this review, we examine the role of systemic mediators such as leptin, ghrelin and insulin, which act in the central nervous system by activating or inhibiting neuropeptide Y, Agouti-related peptide protein, melanocortin, transcript related to cocaine and amphetamine, and others. As a result, modifications in energy homeostasis occur through regulation of appetite and energy expenditure. We also examine compensatory changes in the circulating levels of several peripheral hormones after diet-induced weight loss.
Contido em Archives of endocrinology and metabolism. São Paulo. Vol. 60, no. 2 (Apr. 2016), p. 152-162
Assunto Metabolismo energetico
Peso corporal
Regulação do apetite
[en] Appetite regulation
[en] Body weight
[en] Energy expenditure
[en] Energy metabolism
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/147576
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