Repositório Digital

A- A A+

MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder

.

MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder

Mostrar registro completo

Estatísticas

Título MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder
Autor Guimarães, Ana Paula Miranda
Zeni, Cristian Patrick
Polanczyk, Guilherme Vanoni
Genro, Júlia Pasqualini
Roman, Tatiana
Rohde, Luis Augusto Paim
Hutz, Mara Helena
Abstract The monoamine oxidase A (MAOA) gene has been extensively related to aggressive, impulsive and violent behaviours. Previous studies have documented the improvement of oppositional symptoms in attention deficit hyperactivity disorder (ADHD) patients with methylphenidate (MPH). However, the effect of the MAOA gene in response to MPH has not been investigated. A sample of 85 boys from an ADHD outpatient service was genotyped for the MAOA-uVNTR polymorphism. The outcome measure was the parent-rated oppositional subscale of the Swanson, Nolan and Pelham Scale – version IV. The scale was applied by child psychiatrists blinded to genotype at baseline and in the first and third months of treatment. A significant interaction between the presence of MAOA high-activity genotype and treatment with MPH over time on oppositional scores was detected during the 3 months’ treatment (n=85, F2,136=4.83, p=0.009). These results suggest an effect of the MAOA-uVNTR high-activity genotype on the improvement of oppositional symptoms with MPH treatment.
Contido em International journal of neuropsychopharmacology. Cambridge. Vol. 12, no. 5 (Jun. 2009), p. 709-714
Assunto Diagnóstico
Farmacogenética
Metilfenidato
Monoaminoxidase
Transtorno da falta de atenção com hiperatividade
[en] ADHD
[en] MAOA
[en] Methylphenidate
[en] Oppositional symptoms
[en] Pharmacogenetic
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/148505
Arquivos Descrição Formato
000708852.pdf (77.69Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.