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Diagnosing dementia and normal aging : clinical relevance of brain ratios and cognitive performance in a Brazilian sample

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Diagnosing dementia and normal aging : clinical relevance of brain ratios and cognitive performance in a Brazilian sample

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Título Diagnosing dementia and normal aging : clinical relevance of brain ratios and cognitive performance in a Brazilian sample
Autor Chaves, Marcia Lorena Fagundes
Ilha, Darcy de Oliveira
Maia, Alberto Luiz Grigoli e
Motta, Eduardo
Lehmen, Romnei Lenon
Oliveira, Luciano Machado de
Abstract The main objective of the present study was to evaluate the diagnostic value (clinical application) of brain measures and cognitive function. Alzheimer and multiinfarct patients (N = 30) and normal subjects over the age of 50 (N = 40) were submitted to a medical, neurological and cognitive investigation. The cognitive tests applied were Mini-Mental, word span, digit span, logical memory, spatial recognition span, Boston naming test, praxis, and calculation tests. The brain ratios calculated were the ventricle-brain, bifrontal, bicaudate, third ventricle, and suprasellar cistern measures. These data were obtained from a brain computer tomography scan, and the cutoff values from receiver operating characteristic curves. We analyzed the diagnostic parameters provided by these ratios and compared them to those obtained by cognitive evaluation. The sensitivity and specificity of cognitive tests were higher than brain measures, although dementia patients presented higher ratios, showing poorer cognitive performances than normal individuals. Normal controls over the age of 70 presented higher measures than younger groups, but similar cognitive performance. We found diffuse losses of tissue from the central nervous system related to distribution of cerebrospinal fluid in dementia patients. The likelihood of case identification by functional impairment was higher than when changes of the structure of the central nervous system were used. Cognitive evaluation still seems to be the best method to screen individuals from the community, especially for developing countries, where the cost of brain imaging precludes its use for screening and initial assessment of dementia.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 32, n. 9 (Sept. 1999), p. 1133-1143
Assunto Análise de variância
Demência
Doença de Alzheimer
Envelhecimento : Fisiologia
[en] Aging
[en] Brain ratios
[en] Cognition
[en] Dementia
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/159365
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