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Repair of bone defects using adipose-derived stem cells combined with alpha-tricalcium phosphate and gelatin sponge scaffolds in a rat model

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Repair of bone defects using adipose-derived stem cells combined with alpha-tricalcium phosphate and gelatin sponge scaffolds in a rat model

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Título Repair of bone defects using adipose-derived stem cells combined with alpha-tricalcium phosphate and gelatin sponge scaffolds in a rat model
Autor Corsetti, Adriana
Bahuschewskyj, Claudia
Ponzoni, Deise
Langie, Renan Cavalheiro
Santos, Luis Alberto dos
Camassola, Melissa
Nardi, Nance Beyer
Puricelli, Edela
Abstract Objectives: this study aimed to evaluate the potential of adupose-derived stem cells (ASCs) combined witha modified tricalcium phospate (a-TCP) or gelatin sponge (GS) scaffolds for bone healing in a rat model. Material and Methods: Bone defects were surgically created in the femur of adult SHR rats and filled with the scaffolds, empty or combined with ASCs. The results were analyzed by histology abd histomorphometry on days seven, 13, 30 and 60. Results: Significantly increased bone repair was observed on days seven and 60 in animals treated with a-TCP/ASCs, and on day 14 in the group trated with GS/ASCs, when compared with the groups treated with the biomaterials alone. Intenses fibroplastia was observed in the group trated with GS alone, on days 14 and 30. Conclusions: Our results showed that the use of ascs combined with a-TCP scaffold suggests osteocunductive property that results in a biological support to the cells, whereas the GS scaffold functions just as a carrier. These results confirm the potential os ASCs in accelerating bone repais in in vivo experimental rat models. These results suggest a new alternative for treating bone defects.
Contido em Journal of applied oral science. Bauru. Vol. 25, no. 1 (Jan./Feb. 2017), p. 10-19
Assunto Cálcio
Células-tronco
Regeneração óssea
[en] Adipose-derived stem cells
[en] Bone regeneration
[en] Calcium cement
[en] Rat model
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/163933
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