Repositório Digital

A- A A+

The effects of old and recent migration waves in the distribution of HBB*S globin gene haplotypes

.

The effects of old and recent migration waves in the distribution of HBB*S globin gene haplotypes

Mostrar registro completo

Estatísticas

Título The effects of old and recent migration waves in the distribution of HBB*S globin gene haplotypes
Autor Lindenau, Juliana Dal-Ri
Wagner, Sandrine Comparsi
Castro, Simone Martins de
Hutz, Mara Helena
Abstract Sickle cell hemoglobin is the result of a mutation at the sixth amino acid position of the beta () globin chain. The HBB*S gene is in linkage disequilibrium with five main haplotypes in the -globin-like gene cluster named according to their ethnic and geographic origins: Bantu (CAR), Benin (BEN), Senegal (SEN), Cameroon (CAM) and Arabian-Indian (ARAB). These haplotypes demonstrated that the sickle cell mutation arose independently at least five times in human history. The distribution of S haplotypes among Brazilian populations showed a predominance of the CAR haplotype. American populations were clustered in two groups defined by CAR or BEN haplotype frequencies. This scenario is compatible with historical records about the slave trade in the Americas. When all world populations where the sickle cell gene occurs were analyzed, three clusters were disclosed based on CAR, BEN or ARAB haplotype predominance. These patterns may change in the next decades due to recent migrations waves. Since these haplotypes show different clinical characteristics, these recent migrations events raise the necessity to develop optimized public health programs for sickle cell disease screening and management.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 4 (Oct./Dec. 2016), p. 515-523
Assunto Hemoglobina falciforme
Migração
[en] Globi haplotypes
[en] Hemoglobin S
[en] Migration
[en] Sickle cell disease
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/164369
Arquivos Descrição Formato
001017034.pdf (1.256Mb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.