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Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals

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Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals

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Título Oxytocin and arginine vasopressin receptor evolution : implications for adaptative novelties in placental mammals
Autor Rosa, Pamela Laiz Paré da
Paixão Côrtes, Vanessa Rodrigues
Rodrigues, Luciana Tovo
Pinilla, Pedro Vargas
Viscardi, Lucas Henriques
Salzano, Francisco Mauro
Henkes, Luiz Ernani
Bortolini, Maria Cátira
Abstract Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 4, (Dec. 2016), p. 646-657
Assunto Arginina
Evolução molecular
Oxitocina
[en] Arginine vasopressin receptors
[en] Interaction motifs
[en] Molecular evolution
[en] Oxytocin receptor
[en] Protein disorder
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/164631
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