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Corticosteroids for severe influenza pneumonia : a critical appraisal

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Corticosteroids for severe influenza pneumonia : a critical appraisal

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Título Corticosteroids for severe influenza pneumonia : a critical appraisal
Autor Nedel, Wagner Luís
Nora, David José Garcia
Salluh, Jorge Ibrain Figueira
Lisboa, Thiago Costa
Póvoa, Pedro
Abstract Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit (ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in severe influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials.
Contido em World Journal of Critical Care Medicine. Pleasanton, CA : Baishideng Publishing Group, 2014-. Vol. 5, no. 1 (February 2016), p. 89-95
Assunto Corticosteróides
Influenza humana
Insuficiência respiratória
Pneumonia
Respiração artificial
[en] Corticosteroids
[en] Influenza
[en] Mechanical ventilation
[en] Pneumonia
[en] Respiratory failure
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/165420
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