Repositório Digital

A- A A+

Expression of E-cadherin and involucrin in leukoplakia and oral cancer : an immunocytochemical and immunohistochemical study

.

Expression of E-cadherin and involucrin in leukoplakia and oral cancer : an immunocytochemical and immunohistochemical study

Mostrar registro completo

Estatísticas

Título Expression of E-cadherin and involucrin in leukoplakia and oral cancer : an immunocytochemical and immunohistochemical study
Autor Silva, Alessandra Dutra da
Maraschin, Bruna Jalfim
Laureano, Natalia Koerich
Daroit, Natália Batista
Brochier, Fernanda
Bündrich, Leonardo
Visioli, Fernanda
Rados, Pantelis Varvaki
Abstract To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with oral leukoplakia (n = 30) and oral squamous cell carcinoma (n = 22). Cell scrapings and the biopsy were performed at the site of the lesion and histological slides were prepared for the immunocytochemical analysis of exfoliated oral mucosal cells and for the immunohistochemical analysis of biopsy tissues using E-cadherin and involucrin. Spearman’s correlation and kappa coefficients were used to assess the correlation and level of agreement between the techniques. Immunostaining for E-cadherin and involucrin by both techniques was similar in the superficial layers of the histological sections compared with cell scrapings. However, there was no statistical correlation and agreement regarding the immunocytochemical and immunohistochemical expression of E-cadherin and involucrin in oral leukoplakia (R = 0.01, p = 0.958) (Kappa = 0.017, p = 0.92) or in oral squamous cell carcinoma (R = 0.26, p = 0.206) (Kappa = 0.36, p = 0.07). The immunoexpression of E-cadherin and involucrin in tissues is consistent with the expression patterns observed in exfoliated oral mucosal cells, despite the lack of a statistically significant correlation. There is an association of the histopathological characteristics of leukoplakia with the expression E-cadherin and of the microscopic aspects of oral squamous cell carcinoma with immunohistochemical expression of involucrin.
Contido em Brazilian oral research. Vol. 31 (2017), p. e19, 1-8
Assunto Leucoplasia bucal
Neoplasias bucais
Patologia bucal
[en] Immunohistochemistry
[en] Mouth neoplasms
[en] Pathology
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/166099
Arquivos Descrição Formato
001025563.pdf (1.210Mb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.