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Chlorhexidine with or without alcohol against biofilm formation : efficacy, adverse events and taste preference

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Chlorhexidine with or without alcohol against biofilm formation : efficacy, adverse events and taste preference

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Título Chlorhexidine with or without alcohol against biofilm formation : efficacy, adverse events and taste preference
Autor Santos, Gabriela Otero dos
Milanesi, Fernanda Carpes
Greggianin, Bruna Frizon
Fernandes, Marilene Issa
Oppermann, Rui Vicente
Weidlich, Patrícia
Abstract In recent years, different chlorhexidine formulations have been tested, including an alcohol-free alternative, but the effect of this solution on early biofilm formation is not clear. A crossover, randomized, double-blind clinical trial was conducted to evaluate the effect of two chlorhexidine solutions against supra- and subgingival biofilm formation (NCT#02656251). Thirty-five participants were randomized and asked to rinse twice daily with 15 ml of an alcohol-containing 0.12% chlorhexidine solution, an alcohol-free 0.12% chlorhexidine solution, or placebo. The study was conducted in three experimental periods of 4 days each, with a 10-day washout between the periods. All the experimental periods followed the same protocol, except that the solutions were switched. Biofilm distribution was evaluated every 24 hours by the Plaque-Free Zone Index, during 96 hours. Adverse events were self-reported and sensory evaluation was performed using a hedonic scale. Compared to the placebo, the chlorhexidine solutions resulted in a significantly higher number of surfaces free of plaque over 96 hours (p < 0.01), and were able to prevent subgingival biofilm formation (p < 0.01). The alcohol-free chlorhexidine solution was associated with a lower incidence of adverse events, compared with alcohol-containing chlorhexidine (p < 0.05); it also received better sensory evaluation and acceptance by trial participants, compared with the alcohol-containing chlorhexidine (p = 0.007), and had a similar inhibitory effect on the formation of supra- and subgingival biofilms.
Contido em Brazilian oral research. São Paulo. Vol. 31 (2017), p. e32, 1-9
Assunto Álcoois
Biofilmes
Clorexidina
[en] Alcohols
[en] Chlorhexidine
[en] Cross-over studies
[en] Dental plaque
[en] Mouthwashes
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/166176
Arquivos Descrição Formato
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