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dc.contributor.authorCampos, Leandro Cruzpt_BR
dc.contributor.authorRocha, Marcus Vinicius Vieirapt_BR
dc.contributor.authorWillers, Denise Maria Cunhapt_BR
dc.contributor.authorSilva, Denise Rossatopt_BR
dc.date.accessioned2017-09-07T02:36:04Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/166206pt_BR
dc.description.abstractIntroduction Smear-negative pulmonary TB (SNPT) represents 30–60% of all pulmonary TB cases. The mortality of these patients can reach 25% in populations with high prevalence of HIV infection, and 10–20% of TB transmission at the population level are attributable to SNPT cases. Methods We conducted a retrospective study to evaluate epidemiological, clinical, and radiological characteristics of patients with SNPT and to compare these with patients who were diagnosed as having smear-positive pulmonary TB (SPPT). All adult patients ( 18 years old) with a positive culture for Mycobacterium tuberculosis, and a diagnosis of pulmonary TB were included in the study. Results 198 patients met the inclusion criteria (positive culture for Mycobacterium tuberculosis) and were included in the analysis. Of these patients, 69 (34.8%) were smear positive (SPPT) and 129 (65.2%) were smear negative (SNPT). In univariate analysis, cough, dyspnea, and hemoptysis were less frequent in SNPT patients in comparison with SPPT patients. In a multivariate model, having no cough and no radiographic pattern typical of TB were the characteristics independently associated with a diagnosis of SNPT. Conclusions We found a very high prevalence of SNPT among patients with TB in a setting with high TB and HIV prevalence. The absence of cough in the presence of other symptoms suggestive of TB, and having no radiographic pattern typical of TB where independent predictors of SNPT.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 11, no. 1 (Jan. 2016), e0147933, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTuberculose pulmonarpt_BR
dc.subjectInfecções por HIVpt_BR
dc.subjectMycobacterium tuberculosispt_BR
dc.subjectPrevalênciapt_BR
dc.titleCharacteristics of patients with smear-negative Pulmonary Tuberculosis (TB) in a region with high TB and HIV prevalencept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001047317pt_BR
dc.type.originEstrangeiropt_BR


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