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Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil

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Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil

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Título Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
Autor Longo, Larisse
Ferrari, Jéssica Tonin
Hoss, Giovana Regina Weber
Fratta, Leila Xavier Sinigaglia
Vieira, Sandra Maria Gonçalves
Silveira, Themis Reverbel da
Abreu e Silva, Fernando Antônio de
Sanseverino, Maria Teresa Vieira
Santos, Jorge Luiz dos
Abstract Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.
Contido em Clinical and biomedical research. Porto Alegre. Vol. 37, n. 2 (2017), p. 87-90
Assunto Atresia biliar
Fatores de risco
Hábito de fumar
[en] Biliary atresia
[en] Environmental risk factor
[en] Etiology
[en] Seasonality
[en] Smoking
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/166321
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