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Error-related negativity (ERN) as a transdiagnostic endophenotype for irritability traits in a comunity sample : a rdoc perspective

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Error-related negativity (ERN) as a transdiagnostic endophenotype for irritability traits in a comunity sample : a rdoc perspective

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Título Error-related negativity (ERN) as a transdiagnostic endophenotype for irritability traits in a comunity sample : a rdoc perspective
Autor Souza, Ana Maria Frota Lisboa Pereira de
Orientador Gauer, Gustavo
Data 2017
Nível Mestrado
Instituição Universidade Federal do Rio Grande do Sul. Instituto de Psicologia. Curso de Pós-Graduação em Psicologia.
Assunto Biomarcadores
Endofenótipos
Estados emocionais
Transtornos mentais
[en] Biomarkers
[en] Error-Related Negativity
[en] Flanker
[en] Irritability
Abstract Mental disorders present difficulties in the research of their mechanisms, considering the high levels of comorbidity and the lack of specific neuroscience data to evaluate them. Estipulating deficit circuits in the disorders and the best treatment is a complex task, given the limited comprehension of the factors that correlate to the disorders. The utilization of biomarkers has proved an efficient and reliable alternative to provide precise diagnosis. Among the biomarkers, the Error-Related Negativity component, an event-related cortical potential, has presented high indexes of stability and validity in correlating to anxiety, obsessive, and mood-related mental disorders. The present dissertation evaluated irritability traits in a community sample, using a Flanker task, that has consistently elicited Error-Related Negativity according to the literature. Our results corroborate literature and found a frontocentral negativity, that peaked around 100ms after the commission of an error in the Flanker Task. However, our manipulation of negative feedback did not support literature, and ERN amplitudes were less enhanced post negative feedback. The relationship between irritability and ERN remains unclear. Future studies should, therefore, address these questionings.
Tipo Dissertação
URI http://hdl.handle.net/10183/168878
Arquivos Descrição Formato
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