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dc.contributor.authorViezzer, Christianpt_BR
dc.contributor.authorForte, Maria Madalena de Camargopt_BR
dc.contributor.authorBerutti, Felipe Amorimpt_BR
dc.contributor.authorAlves, Annelise Kopppt_BR
dc.contributor.authorBergmann, Carlos Perezpt_BR
dc.date.accessioned2018-03-23T02:26:24Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn2576-4519pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/173745pt_BR
dc.description.abstractCell-cell and material-cell interactions have been identified as key factors modulating cellular differentiation and extracellular matrix (ECM) production. Stem cells, in vivo and in vitro cells cultures, respond to biological signals received by their microenvironment surroundings. Via this stimulation, cells can secrete many factors to modulate their microenvironment and activate progenitor cells. This induction results in an increase in the expression of ECM proteins that are associated with cellular adhesion and proliferation and matrix mineralization. Based on the hypothesis that nanostructures can influence steam cell signalization, a long-standing goal has been fabricating a scaffold of polyhydroxybutyrate (PHB) with hydroxyapatite (HAp) incorporated to imitate a bone ECM. Using the electrospinning technique, it is possible to fabricate micro and nanostructured scaffolds. Structural characterization and viability evaluation of these scaffolds, such as adhesion and cellular proliferation, have demonstrated that scaffolds exhibit biocompatibility. Scaffolds containing HAp produce a mineralized matrix, which shows that mesenchymal stem cells differentiate to the osteogenic lineage. These scaffolds have accordingly been shown to have bone regeneration applicability in sites that are not subject to excessive loads.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMOJ Applied bionics and biomechanics [recurso eletrônico]. Edmond. vol. 1, no. 6 (2017), art. 00035, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEngenharia de tecidospt_BR
dc.subjectBone tissue engineeringen
dc.subjectNanostructuresen
dc.subjectOsso e ossospt_BR
dc.subjectHidroxiapatitapt_BR
dc.subjectHydroxyapatiteen
dc.subjectPolyhydroxybutyrateen
dc.subjectPolihidroxibutiratopt_BR
dc.subjectStem cellsen
dc.subjectCélulas-troncopt_BR
dc.subjectMineralized matrixen
dc.subjectNanoestruturaspt_BR
dc.titleEffect of electrospun Phb and Hap-Phb composite scaffolds characteristics on mesenchymal stem cell growth viabilitypt_BR
dc.title.alternativeEffect of electrospun polyhydroxybutyrate and hydroxyapatite-polyhydroxybutyrate composite scaffolds characteristics on mesenchymal stem cell growth viability pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001060477pt_BR
dc.type.originEstrangeiropt_BR


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