Mostrar registro simples

dc.contributor.authorDelgado, Vera Beatrizpt_BR
dc.contributor.authorIzquierdo, Ivan Antoniopt_BR
dc.contributor.authorChaves, Marcia Lorena Fagundespt_BR
dc.date.accessioned2018-08-23T02:31:29Zpt_BR
dc.date.issued2005pt_BR
dc.identifier.issn1178-2021pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/181290pt_BR
dc.description.abstractWith the hypothesis that depression affects memory through a mechanism other than that of the benzodiazepines, the present study evaluated the acute effect of diazepam 10 mg upon explicit memory in patients with major depression. A double-blind, placebo (starch 50 mg) controlled experiment was carried out with 19 patients randomly divided into diazepam (n = 10) and placebo (n = 9) groups. They were evaluated by the Mini-Mental State Examination, and tests were conducted for immediate and delayed (short-term) memory with emotionally toned stimuli (negative, positive, neutral), recognition, and semantic memory in visual or auditory modality. The Visual Analog Mood scale (VAMS) was applied to measure anxiety and mood changes after the administration of drugs (30 minutes and 6 hours). Higher scores in the positively toned list among patients who received diazepam were observed, at the 30-minute compared with the 6-hour evaluation. The recall index of positive words in the diazepam group was positive and significantly different from the index of the placebo group. No anterograde amnesia following diazepam was observed. The neural model of a dysfunction of limbic prefrontal cortical structures that impairs the modulation of the amygdala in major depression may explain the present results. Consequently, the action of diazepam on the amygdala, which has been proposed to be the basis of its anxiolytic action, might be altered, modifying the modulation of memory in our patients.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNeuropsychiatric disease and treatment. Auckland. Vol. 1, no. 3 (2005), p. 269-275pt_BR
dc.rightsOpen Accessen
dc.subjectDepressãopt_BR
dc.subjectMajor depressionen
dc.subjectDiazepamen
dc.subjectDiazepampt_BR
dc.subjectTonsila do cerebelopt_BR
dc.subjectEmotional memory tasksen
dc.subjectAmygdalaen
dc.subjectMemóriapt_BR
dc.titleDifferential effects of acute diazepam on emotional and neutral memory tasks in acutely hospitalized depressed patientspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000535835pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples