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dc.contributor.authorHenriques, João Antonio Pêgaspt_BR
dc.contributor.authorMoreno, Paulo Roberto Hrihorowitschpt_BR
dc.contributor.authorVon Poser, Gilsane Linopt_BR
dc.contributor.authorQuerol, Carmen Botopt_BR
dc.contributor.authorHenriques, Amelia Teresinhapt_BR
dc.date.accessioned2010-04-16T08:54:08Zpt_BR
dc.date.issued1991pt_BR
dc.identifier.issn0074-0276pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/19219pt_BR
dc.description.abstractBecause of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMemorias do Instituto Oswaldo Cruz : an International Journal of Biological and Biomedical Research. Rio de Janeiro. Vol. 86, supl. II (1991), p. 71-74pt_BR
dc.rightsOpen Accessen
dc.subjectAlcalóidespt_BR
dc.subjectAlkaloídsen
dc.subjectSos chromotestept_BR
dc.subjectSOS-chromotesten
dc.subjectSaccharomyces cerevisiaeen
dc.subjectSaccharomyces cerevisiaept_BR
dc.subjectGenotoxicidadept_BR
dc.subjectMutationen
dc.subjectRecombinationen
dc.titleGenotoxic effect of alkaloidspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000003844pt_BR
dc.type.originNacionalpt_BR


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