Repositório Digital

A- A A+

Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration

.

Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration

Mostrar registro completo

Estatísticas

Título Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
Autor Vieira, Silvia Regina Rios
Goldstein, Ivan
Lenaour, Gilles
Marquette, Charles-Hugo
Rouby, Jean-Jacques
Experimental ICU Study Group
Abstract Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration.
Contido em Brazilian journal of infectious diseases. Salvador. Vol. 7, n. 3 (jun. 2003), 216-223
Assunto Pneumonia : Etiologia
Ventilação mecânica : Efeitos adversos
[en] Ventilator associated pneumonia
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/19704
Arquivos Descrição Formato
000387893.pdf (52.23Kb) Texto completo Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.