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Implications of the hemodynamic optimization approach guided by right heart catheterization in patients with severe heart failure

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Implications of the hemodynamic optimization approach guided by right heart catheterization in patients with severe heart failure

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Título Implications of the hemodynamic optimization approach guided by right heart catheterization in patients with severe heart failure
Autor Rohde, Luis Eduardo Paim
Furian, Thiago Quedi
Campos, Candice P.
Biolo, Andreia
Silva, Eneida Rejane Rabelo da
Foppa, Murilo
Clausell, Nadine Oliveira
Abstract Objective - To report the hemodynamic and functional responses obtained with clinical optimization guided by hemodynamic parameters in patients with severe and refractory heart failure. Methods - Invasive hemodynamic monitoring using right heart catheterization aimed to reach low filling pressures and peripheral resistance. Frequent adjustments of intravenous diuretics and vasodilators were performed according to the hemodynamic measurements. Results - We assessed 19 patients (age = 48±12 years and ejection fraction = 21±5%) with severe heart failure. The intravenous use of diuretics and vasodilators reduced by 12 mm Hg (relative reduction of 43%) pulmonary artery occlusion pressure (P<0.001), with a concomitant increment of 6 mL per beat in stroke volume (relative increment of 24%, P<0.001) We observed significant associations between pulmonary artery occlusion pressure and mean pulmonary artery pressure (r=0.76; P<0.001) and central venous pressure (r=0.63; P<0.001). After clinical optimization, improvement in functional class occurred (P< 0.001), with a tendency towards improvement in ejection fraction and no impairment to renal function. Conclusion - Optimization guided by hemodynamic parameters in patients with refractory heart failure provides a significant improvement in the hemodynamic profile with concomitant improvement in functional class. This study emphasizes that adjustments in blood volume result in immediate benefits for patients with severe heart failure.
Contido em Arquivos brasileiros de cardiologia. São Paulo. Vol. 78, n. 3 (mar. 2002), p. 261-266
Assunto Cateterismo cardíaco
Débito cardíaco
Diuréticos
Hemodinâmica
Insuficiência cardíaca : Terapia
Pressão ventricular
Vasodilatadores
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/19721
Arquivos Descrição Formato
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