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dc.contributor.authorNascente, Patrícia da Silvapt_BR
dc.contributor.authorNobre, Márcia de Oliveirapt_BR
dc.contributor.authorSchuch, Luiz Filipept_BR
dc.contributor.authorLucia-Junior, Thomazpt_BR
dc.contributor.authorFerreiro, Laertept_BR
dc.contributor.authorMeireles, Mário Carlos Araújopt_BR
dc.date.accessioned2010-04-16T09:11:41Zpt_BR
dc.date.issued2003pt_BR
dc.identifier.issn1517-8382pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/19808pt_BR
dc.description.abstractMalassezia pachydermatis is recognized as a normal inhabitant and an opportunistic pathogen of the external ear canal and skin of dogs and cats. In especial clinical conditions, and mainly in the cases of therapeutic failure related to external otitis and dermatitis complicated by this yeast, it is recommended test susceptibility to antifungal drugs. The purpose of this work was to evaluate the susceptibility of 44 isolates of M. pachydermatis from the external ear canal and skin of dogs and cats using two different in vitro antifungal susceptibility methods: the Etest® and the broth microdilution method. Thirty-five samples were tested using the Etest®, twenty-four samples were tested using the broth microdilution method and fifteen samples were tested using both tests. The antifungal agents used were ketoconazole (KTZ), fluconazole (FLZ) and itraconazole (ITZ). In the broth microdilution method the yeast was less susceptible to ITZ while KTZ had the strongest activity. On the other hand, the Etest® showed that M. pachydermatis was more susceptible to ITZ while the less active drug was FLZ. The simultaneous evaluation using both methods identified FLZ as the antifungal drug with the highest activity (64.3%), followed by KTZ (57.1%) and ITZ (28.6%). These results showed that there is an urgent need to standardize of the values considered as parameters for growth inhibition of this yeast so a simple and efficient method can be used routinely in the laboratory practice.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian Journal of Microbiology. São Paulo, SP. Vol. 34, n. 4 (dez. 2003), p. 359-362pt_BR
dc.rightsOpen Accessen
dc.subjectMalassezia pachydermatis.en
dc.subjectMalassezia pachydermatispt_BR
dc.subjectEtest®en
dc.subjectFluconazolpt_BR
dc.subjectBroth microdilution methoden
dc.subjectKetoconazoleen
dc.subjectItraconazoleen
dc.subjectFluconazoleen
dc.titleEvaluation of Malassezia pachydermatis antifungical susceptibility using two different methodspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000422539pt_BR
dc.type.originNacionalpt_BR


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