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Evaluation of oxacillin and cefoxitin disks for detection of resistance in coagulase negative staphylococci

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Evaluation of oxacillin and cefoxitin disks for detection of resistance in coagulase negative staphylococci

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Título Evaluation of oxacillin and cefoxitin disks for detection of resistance in coagulase negative staphylococci
Autor Antunes, Ana Lucia Souza
Secchi, Carina
Reiter, Keli Cristine
Perez, Leandro Reus Rodrigues
Freitas, Ana Lucia Peixoto de
D'Azevedo, Pedro Alves
Abstract Coagulase-negative Staphylococcus spp. was considered nonpathogenic until the emergence of multiresistance and the demonstration of their participation as infectious agents. In Brazil, oxacillin resistance may be present in over 80% of isolates, and the Clinical and Laboratory Standards Institute standardized a diskdiffusion method to predict this resistance in Staphylococcus. The aim of this study was to evaluate the variability among commercial disks of oxacillin (1 μg) and cefoxitin (30 μg) widely used in clinical laboratories of microbiology, compared with mecA gene and minimum inhibitory concentration (MIC) of oxacillin. The use of oxacillin and cefoxitin disks simultaneously allowed the detection of important differences, particularly, in less frequent species such as S. cohnii, S. haemolyticus, S. saprophyticus, and S. sciuri. Disks of cefoxitin of the brand 2 displayed good correlation with the mecA gene (98.7%) and oxacillin MIC (97.8%), while major discrepancies were observed using disks of brand 1. One of the critical points in the diffusion disk test is the quality of the disks: the use of better quality disks associated with molecular methods lead to better results to define the best antibiotic therapy.
Contido em Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 102, n. 6 (Sept. 2007), p. 719-723
Assunto Resistência bacteriana
Staphylococcus coagulase negativo
[en] Cefoxitin
[en] coagulase negative staphylococci
[en] MecA gene
[en] methicillin resistance
[en] Susceptibility tests
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/20522
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