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CLSI broth microdilution method for testing susceptibility of Malassezia pachydermatis to thiabendazole

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CLSI broth microdilution method for testing susceptibility of Malassezia pachydermatis to thiabendazole

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Título CLSI broth microdilution method for testing susceptibility of Malassezia pachydermatis to thiabendazole
Autor Nascente, Patrícia da Silva
Meinerz, Ana Raquel Mano
Faria, Renata Osório de
Schuch, Luiz Filipe Damé
Meireles, Mário Carlos Araújo
Mello, Joao Roberto Braga de
Abstract Thiabendazole, classified as antiparasitic and also used as an antifungal drug, can be found as otological solution indicated for treatment of parasitic and fungal external otitis in small animals. Malassezia pachydermatis is a yeast recognized as a normal inhabitant on the skin and mucous membranes of dogs and cats. However, it is considered an opportunistic agent that causes external otitis and dermatitis in these animals. The aim of this study was to evaluate the in vitro effect of thiabendazole against 51 isolates of M. pachydermatis using the CLSI Broth Microdilution method that has been adapted for this yeast species (NCCLS, 2002). Based on this test, the Minimum Inhibitory Concentrations (MIC) of thiabendazol was calculated. Subsequently, the susceptibility of each isolate against this antifungal was determined. It was observed that the MIC of thiabendazole against M. pachydermatis ranged from 0.03 to > 4 μg/mL. A total of 13.7% of the isolates were found to be resistant, 47.1% were intermediate and 39.2% were sensitive to the drug. The rate of resistance of the yeasts against thiabendazole was similar to the results previously obtained with other antifungals, while the adapted broth microdilution technique used in this study proved to be efficient.
Contido em Brazilian journal of microbiology. São Paulo. Vol. 40, no. 2 (Apr./June 2009), p. 222-226
Assunto Fungos
Malassezia
Tiabendazol
[en] Malassezia pachydermatis
[en] Minimum Inhibitory Concentration
[en] Thiabendazole
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/20803
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