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Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

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Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

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Título Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Autor Furlanetto, Tania Weber
Nunes Junior, R. B.
Sopelsa, Andreia Maria Ida
Maciel, R.M.B.
Abstract Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263
Assunto Estradiol : Uso terapeutico
Iodetos
Ratos
[en] Estradiol
[en] Follicular cells
[en] Iodide uptake
[en] Thyroid
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21115
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