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Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography

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Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography

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Título Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography
Autor Manfroi, Waldomiro Carlos
Zago, Alcides José
Cruz, Rosana
Oliveira, Juliana
Kirschnick, Luciana Schmidt
Ordovas, Karen Gomes
Candiago, Rafael Henriques
Souza, Josiane de
Ribeiro, Luciane Weiss
Leitão, Cristiane Bauermann
Brizolara, Maria Luiza
Abstract Many clinical and epidemiological studies have demonstrated the relationship between serum ferritin and ischemic heart disease. In the present study we evaluated the relationship between coronary heart disease (CHD) and serum ferritin levels in patients submitted to coronary arteriography. We evaluated 307 patients (210 (68.7%) males; median age: 60 years) who were submitted to coronary angiography, measurement of serum ferritin and identification of clinical events of ischemic heart disease. Serum ferritin is reported as quartiles. Ninety-six patients (31.27%) had normal coronary angiography (group 1) and 211 (68.73%) had coronary heart disease (group 2). Of the patients with CHD, 61 (28.9%) had serum ferritin levels higher than 194 ng/ml (4th quartile), as opposed to only 14 (14.58%) of those without CHD (P = 0.0067). In the 2nd quartile, 39 patients (18.48%) had CHD, while 35 patients (36.46%) had normal coronary arteries (P = 0.00064). Multivariate analysis of the data showed that the difference between groups was not statistically significant (P = 0.33). We conclude that there is no independent relationship between coronary heart disease and increased levels of serum ferritin.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 32, no. 3 (Mar. 1999), p. 303-307
Assunto Angiografia coronária
Doença da artéria coronariana
Ferritinas
[en] Atherosclerosis
[en] Coronary arteriography
[en] Coronary heart disease
[en] Ferritin
[en] Risk factors
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21130
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