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Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

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Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

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Título Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease
Autor Simon, Daniel
Paludo, Crislaine A.
Ghisleni, Gabriele Cordenonzi
Manfroi, Waldomiro Carlos
Roisenberg, Israel
Abstract High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 709-714
Assunto Doenças cardiovasculares
Fatores de risco
[en] Coronary artery disease
[en] DNA polymorphisms
[en] Risk factor
[en] Von Willebrand factor
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21131
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