|Título||Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease
Paludo, Crislaine A.
Ghisleni, Gabriele Cordenonzi
Manfroi, Waldomiro Carlos
|Abstract||High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.
|Contido em||Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 709-714
Fatores de risco
[en] Coronary artery disease
[en] DNA polymorphisms
[en] Risk factor
[en] Von Willebrand factor
|Tipo||Artigo de periódico
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