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dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.contributor.authorBittencourt, Ana Paula Santana de Vasconcellospt_BR
dc.contributor.authorCucco, Simone Nascimento Silveirapt_BR
dc.contributor.authorDalmaz, Carlapt_BR
dc.date.accessioned2010-04-24T04:15:27Zpt_BR
dc.date.issued2001pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21135pt_BR
dc.description.abstractThere is extensive evidence that acute stress induces an analgesic response in rats. On the other hand, repeatedly stressed animals may present the opposite effect, i.e., hyperalgesia. Furthermore, exposure to novelty is known to induce antinociception. The effects of repeated restraint stress on nociception after exposure to novelty, as measured by the tail-flick latency (TFL), were studied in adult male rats. The animals were stressed by restraint 1 h daily, 5 days a week for 40 days. The control group was not submitted to restraint. Nociception was assessed with a tail-flick apparatus. After being familiarized with the TFL apparatus, each group was subdivided into two other groups, i.e., with or without novelty. Animals were subjected to the TFL measurement twice. For the animals exposed to novelty, the first TFL measurement was made immediately before, and the second 2 min after a 2- min exposure to a new environment. While the control group presented an increased TFL after exposure to a novel environment, chronically stressed animals did not show this effect. These results suggest that repeated restraint stress induces an alteration in the nociceptive response, perhaps as a result of an alteration in endogenous opioids in these animals.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 241-244pt_BR
dc.rightsOpen Accessen
dc.subjectPainen
dc.subjectBioquímicapt_BR
dc.subjectStressen
dc.subjectRepeated stressen
dc.subjectNociceptionen
dc.subjectNoveltyen
dc.titleEffect of repeated stress on novelty-induced antinociception in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000327061pt_BR
dc.type.originNacionalpt_BR


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