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Lung clearance of 99m TC-DTPA in systemic lupus erythematosus

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Lung clearance of 99m TC-DTPA in systemic lupus erythematosus

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Título Lung clearance of 99m TC-DTPA in systemic lupus erythematosus
Autor Dalcin, Paulo de Tarso Roth
Menna Barreto, Sérgio Saldanha
Cunha, Renato Duarte da
Xavier, Ricardo Machado
Brenol, João Carlos Tavares
Marroni, Belmonte Juarez
Abstract The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85- 92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 35, no. 6 (June 2002), p. 663-668
Assunto Estudos de casos e controles
Lupus eritematoso sistêmico
Permeabilidade capilar
Pulmao : Irrigação sanguínea
[en] Pulmonary epithelial permeability
[en] Technetium-99m-labeled diethylenetriamine pentaacetic acid
[en] Lung clearance
[en] Systemic lupus erythematosus
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21143
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