Repositório Digital

A- A A+

Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats

.

Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats

Mostrar registro completo

Estatísticas

Título Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
Autor D'Avila, Katia de Angelis Lobo
Oliveira, Álvaro Reischak de
Dall'Ago, Pedro
Peixoto, Lívia Rodrigues Araújo
Gadonski, Giovani
Lacchini, Silvia
Fernandes, Tania Regina Gattelli
Irigoyen, Maria Claudia Costa
Abstract Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 6 (June 2000), p. 635-641
Assunto Diabete : Frequencia cardiaca : Pressao arterial : Ratos
Exercicio : Fisiologia
[en] Arterial pressure
[en] Autonomic control
[en] Exercise training
[en] Experimental diabetes
[en] Myocardial contractility
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21155
Arquivos Descrição Formato
000295587.pdf (152.5Kb) Texto completo Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.