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Oxidative stress in the latissimus dorsi muscle of diabetic rats

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Oxidative stress in the latissimus dorsi muscle of diabetic rats

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Título Oxidative stress in the latissimus dorsi muscle of diabetic rats
Autor D'Avila, Katia de Angelis Lobo
Cestari, Idagene Aparecida
Barp, Jaqueline
Dall'Ago, Pedro
Fernandes, Tania Regina Gattelli
Bittencourt Junior, Paulo Ivo Homem de
Belló-Klein, Adriane
Bello, Antonio Andrea
Llesuy, Susana Francisca
Irigoyen, Maria Claudia Costa
Abstract The purpose of the present study was to investigate the effects of experimental diabetes on the oxidant and antioxidant status of latissimus dorsi (LD) muscles of male Wistar rats (220 ± 5 g, N = 11). Shortterm (5 days) diabetes was induced by a single injection of streptozotocin (STZ, 50 mg/kg, iv; glycemia >300 mg/dl). LD muscle of STZdiabetic rats presented higher levels of thiobarbituric acid reactive substances (TBARS) and chemiluminescence (0.36 ± 0.02 nmol/mg protein and 14706 ± 1581 cps/mg protein) than LD muscle of normal rats (0.23 ± 0.04 nmol/mg protein and 7389 ± 1355 cps/mg protein). Diabetes induced a 92% increase in catalase and a 27% increase in glutathione S-transferase activities in LD muscle. Glutathione peroxidase activity was reduced (58%) in STZ-diabetic rats and superoxide dismutase activity was similar in LD muscle of both groups. A positive correlation was obtained between catalase activity and the oxidative stress of LD, as evaluated in terms of TBARS (r = 0.78) and by chemiluminescence (r = 0.89). Catalase activity also correlated inversely with glutathione peroxidase activity (r = 0.79). These data suggest that an increased oxidative stress in LD muscle of diabetic rats may be related to skeletal muscle myopathy.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 11 (Nov. 2000), p. 1363-1368
Assunto Fisiologia
[en] Catalase
[en] Glutathione
[en] Latissimus dorsi muscle
[en] Oxidative stress
[en] Streptozotocin-diabetes
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21175
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