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Dose-related effects of propericiazine in rats

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Dose-related effects of propericiazine in rats

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Título Dose-related effects of propericiazine in rats
Autor Cechin, Edson Machado
Quevedo, João Luciano de
Barichello, Tatiana
Vieira, Rodrigo Machado
Gentil Filho, Valentim
Kapczinski, Flávio Pereira
Abstract We evaluated the effects of the neuroleptic agent propericiazine on animal models of anxiety and memory. Adult male Wistar rats (250 to 350 g) received intraperitoneal injections of propericiazine (0.05, 0.075 and 0.1 mg/kg), diazepam (1 mg/kg), saline, or diazepam vehicle (20% propylene glycol and 80% saline) 30 min prior to the experimental procedure. Animals (10-15 for each task) were tested for step-down inhibitory avoidance (0.3-mA footshock) and habituation to an open-field for memory assessment, and submitted to the elevated plus-maze to evaluate the effects of propericiazine in a model of anxiety. Animals treated with 0.075 mg/kg propericiazine showed a reduction in anxiety measures (P<0.05) similar to that observed in those treated with diazepam. Propericiazine at the doses of 0.05 and 0.1 mg/kg had no significant anxiolytic effects (P>0.05) in the elevated plus-maze model of anxiety. Memory was not affected by propericiazine in any of the tests, but was impaired by diazepam. The results indicate a dose-related, inverse U-shaped effect of propericiazine in an anxiety model, but not on memory tasks, perhaps reflecting involvement of the dopaminergic system in the mechanisms of anxiety.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 2 (2003), p. 227-231
Assunto Efeito de drogas
Fenotiazinas
Memória
Ratos
Transtornos da ansiedade
[en] Anxiety
[en] Diazepam
[en] Elevated plus-maze
[en] Memory
[en] Propericiazine
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21177
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