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Relationship between cardiovascular dysfunction and hyperglycemis in streptozotocin-induced diabetes in rats

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Relationship between cardiovascular dysfunction and hyperglycemis in streptozotocin-induced diabetes in rats

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Título Relationship between cardiovascular dysfunction and hyperglycemis in streptozotocin-induced diabetes in rats
Autor Schaan, Beatriz D'Agord
Dall'Ago, Pedro
Maeda, Celso Yuji
Ferlin, Elton Luiz
Fernandes, Tania Regina Gattelli
Schmid, Helena
Irigoyen, Maria Claudia Costa
Abstract Streptozotocin (STZ)-induced diabetes in rats is characterized by cardiovascular dysfunction beginning 5 days after STZ injection, which may reflect functional or structural autonomic nervous system damage. We investigated cardiovascular and autonomic function, in rats weighing 166 ± 4 g, 5-7, 14, 30, 45, and 90 days after STZ injection (N = 24, 33, 27, 14, and 13, respectively). Arterial pressure (AP), mean AP (MAP) variability (standard deviation of the mean of MAP, SDMMAP), heart rate (HR), HR variability (standard deviation of the normal pulse intervals, SDNN), and root mean square of successive difference of pulse intervals (RMSSD) were measured. STZ induced increased glycemia in diabetic rats vs control rats. Diabetes reduced resting HR from 363 ± 12 to 332 ± 5 bpm (P < 0.05) 5 to 7 days after STZ and reduced MAP from 121 ± 2 to 104 ± 5 mmHg (P = 0.007) 14 days after STZ. HR and MAP variability were lower in diabetic vs control rats 30-45 days after STZ injection (RMSSD decreased from 5.6 ± 0.9 to 3.4 ± 0.4 ms, P = 0.04 and SDMMAP from 6.6 ± 0.6 to 4.2 ± 0.6 mmHg, P = 0.005). Glycemia was negatively correlated with resting AP and HR (r = -0.41 and -0.40, P < 0.001) and with SDNN and SDMMAP indices (r = -0.34 and -0.49, P < 0.01). Even though STZ-diabetic rats presented bradycardia and hypotension early in the course of diabetes, their autonomic function was reduced only 30-45 days after STZ injection and these changes were negatively correlated with plasma glucose, suggesting a metabolic origin.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 37, no. 12 (Dec. 2004), p. 1895-1902
Assunto Fisiologia
[en] Arterial pressure variability
[en] Autonomic nervous system
[en] Diabetes
[en] Heart rate variability
[en] Rats
[en] Streptozotocin
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21185
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