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Heterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejection

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Heterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejection

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Título Heterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejection
Autor Saueressig, Mauricio Guidi
Edelweiss, Maria Isabel Albano
Souza, Fabiano H.
Moreschi, Alexandre Heitor
Savegnago, Fabrício L.
Macedo Neto, Amarilio Vieira de
Abstract An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 ± 0.43, P ≤ 0.001) when compared to the autograft and glycerinpreserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerinpreserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 38, no. 7 (July 2005), p. 1071-1075
Assunto Glicerol
Mucosa respiratória
Rejeição de enxerto
Tranplante
Traquéia : Transplante
[en] Glycerol
[en] Graft rejection
[en] Respiratory mucosa
[en] Trachea
[en] Transplantation
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21186
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