Repositório Digital

A- A A+

Frequency of CCR5delta32 in brazilian populations

.

Frequency of CCR5delta32 in brazilian populations

Mostrar registro completo

Estatísticas

Título Frequency of CCR5delta32 in brazilian populations
Autor Vargas, Andréia Escosteguy
Marrero, Andrea Rita
Salzano, Francisco Mauro
Bortolini, Maria Cátira
Chies, Jose Artur Bogo
Abstract A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5Δ32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5Δ32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, n. 3 (Mar. 2006), p. 321-325
Assunto Genética de populações
[en] Brazilian population
[en] CCR5
[en] Chemokine receptors
[en] Gene flow
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21200
Arquivos Descrição Formato
000559818.pdf (476.3Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.