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dc.contributor.authorVargas, Andréia Escosteguypt_BR
dc.contributor.authorMarrero, Andrea Ritapt_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorBortolini, Maria Cátirapt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.date.accessioned2010-04-24T04:15:41Zpt_BR
dc.date.issued2006pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21200pt_BR
dc.description.abstractA sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5Δ32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5Δ32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, n. 3 (Mar. 2006), p. 321-325pt_BR
dc.rightsOpen Accessen
dc.subjectGenética de populaçõespt_BR
dc.subjectCCR5en
dc.subjectChemokine receptorsen
dc.subjectBrazilian populationen
dc.subjectGene flowen
dc.titleFrequency of CCR5delta32 in brazilian populationspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000559818pt_BR
dc.type.originNacionalpt_BR


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