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Aversive stimulation during the stress-hyporesponsive period does not affect the number of corticotroph cells in neonatal male rats

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Aversive stimulation during the stress-hyporesponsive period does not affect the number of corticotroph cells in neonatal male rats

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Título Aversive stimulation during the stress-hyporesponsive period does not affect the number of corticotroph cells in neonatal male rats
Autor Lucion, Aldo Bolten
Aguiar, Claudia Enk de
Stefani, Luciana Paula Cadore
Padoin, Maristela Jorge
Coutinho, Ligia Maria Barbosa
Abstract Immunohistochemistry was used to evaluate the effects of neonatal handling and aversive stimulation during the first 10 days of life on the number of corticotrophs in the anterior lobe of the pituitary of 11-dayold male Wistar rats. Since adult rats handled during infancy respond with reduced corticosterone secretion in response to stressors and with less behavior inhibition in novel environments, we assumed that neonatal stimulation could affect pituitary morphology during this critical period of cell differentiation. Three groups of animals were studied: intact (no manipulation, N = 5), handled (N = 5) and stimulated (submitted to 3 different aversive stimuli, N = 5). The percentage of ACTH-immunoreactive cells in the anterior lobe of the pituitary (number of ACTH-stained cells divided by total number of cells) was determined by examining three slices per pituitary in which a minimum of 200 cells were counted by two independent researchers. Although animals during the neonatal period are less reactive to stresslike stimulation in terms of ACTH and corticosterone secretion, results showed that the relative number of ACTH-stained cells of neonatal handled (0.25 ± 0.01) and aversive stimulated (0.29 ± 0.03) rats was not significantly different from intact (0.30 ± 0.03) animals. Neonatal stimulation may have a differential effect on the various subpopulations of corticotroph cells in the anterior pituitary.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 30, n. 12 (1997), p. 1463-1466
Assunto Fisiologia
[en] ACTH
[en] Immunohistochemistry
[en] Neonatal handling
[en] Pituitary
[en] Stress
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21204
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