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Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis

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Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis

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Título Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis
Autor Lima, José Eduardo de Paula
Walz, Roger
Tort, Adriano Bretanha Lopes
Souza, Diogo Onofre Gomes de
Portela, Luis Valmor Cruz
Bianchin, Marino Muxfeldt
Takayanagui, Osvaldo Massaiti
Leite, João Pereira
Abstract The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, no. 1 (Jan. 2006), p. 129-135
Assunto Neurocisticercose
Proteínas S100
[en] Albumin quotient
[en] Cerebrospinal fluid
[en] Glial marker
[en] Neurocysticercosis
[en] S100B
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21214
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