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Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats

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Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats

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Título Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Autor Veiga, Caroline Perinazzo da
Miczek, Klaus Alexander
Lucion, Aldo Bolten
Almeida, Rosa Maria Martins de
Abstract Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (June 2007), p. 825-830
Assunto Receptores de serotonina
Serotonina : Comportamento : Agressividade : Ratas
[en] 5-HT receptors
[en] Aggression
[en] Maternal behavior
[en] Prefrontal cortex
[en] Serotonin
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21218
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