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Apolipoprotein CIII polymorphism and triglyceride levels of a japanese population living in southern Brazil

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Apolipoprotein CIII polymorphism and triglyceride levels of a japanese population living in southern Brazil

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Título Apolipoprotein CIII polymorphism and triglyceride levels of a japanese population living in southern Brazil
Autor Parzianello, Leandro
Volpe, Graziela de Oliveira
Coelho, Janice Carneiro
Abstract Apolipoprotein CIII (apo-CIII) participates in the regulation of triglyceride-rich lipoprotein metabolism. Several polymorphic sites have been detected within and around the apo-CIII gene. Here, we examined the relationship between apo-CIII Sst I polymorphism (CC, CG, GG genotypes) and plasma triglyceride (TG) levels in a group of 159 Japanese individuals living in Southern Brazil. The sample was divided into a group of Japanese descendants (N = 51) with high TG (HTG; >200 mg/dL) and a group of Japanese descendants (N = 108) with normal TG (NTG; <200 mg/dL). TG and total cholesterol levels were analyzed by an enzymatic method using the Labtest-Diagnostic kit and high- and low-density lipoproteins by a direct method using the Labtest-Diagnostic kit and DiaSys Diagnostic System International kit, respectively. A 428-bp sequence of apo-CIII gene was amplified using oligonucleotide primers 5' GGT GAC CGA TGG CTT CAG TTC CCT GA 3' and 5' CAG AAG GTG GAT AGA GCG CTG GCC T 3'. The PCR products were digested with a restriction endonuclease Sst I. Rare G allele was highly prevalent in our study population (0.416) compared to Caucasians (0.00-0.11). G allele was almost two times more prevalent in the HTG group compared to the NTG group (P < 0.001). The genotype distribution was consistent with the Hardy-Weinberg equilibrium. There was a significant association between rare G allele and HTG in Japanese individuals living in Southern Brazil as indicated by one-way ANOVA, P < 0.05.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 41, n.6 (June 2008), p. 462-467
Assunto Apolipoproteína C-III
Polimorfismo
Triglicerídeos
[en] Apolipoprotein CIII
[en] Japanese population
[en] Sst I polymorphism
[en] Triglycerides
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21228
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