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dc.contributor.authorBau, Paulo Fernando Dottopt_BR
dc.contributor.authorBau, Claiton Henrique Dottopt_BR
dc.contributor.authorNaujorks, Alexandre Antoniopt_BR
dc.contributor.authorRosito, Guido Bernardo Aranhapt_BR
dc.contributor.authorFuchs, Flávio Dannipt_BR
dc.date.accessioned2010-04-24T04:15:53Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21229pt_BR
dc.description.abstractThe higher incidence of cardiovascular events in the morning is accompanied by an increased vascular tone. However, there are few published studies designed to evaluate the diurnal variation of vascular and endothelial parameters in healthy subjects. In the present investigation, we evaluated the diurnal variation in brachial artery diameter (BAD), flow-mediated dilation (FMD) and endothelium-independent dilation (NFMD) in a homogeneous sample of healthy non-smoker young men. Fifty subjects aged 20.8 ± 0.3 years (range: 18 to 25 years) were investigated by brachial artery ultrasound. Exclusion criteria were female gender and evidence of clinically significant health problems, including obesity. Volunteers were asked to rest and avoid fat meals as well as alcoholic beverages 48 h before and until completion of the evaluations. BAD, FMD and NFMD were measured at 7 am, 5 pm, and 10 pm and tested by repeated measures ANOVA. BAD was smaller at 7 am (mean ± SEM, 3.8 ± 0.1 mm) in comparison with 5 pm (3.9 ± 0.1) and 10 pm (4.0 ± 0.1 mm; P < 0.001). FMD values did not change significantly during the day, while NFMD increased more at 7 am (18.5 ± 1.1%), when compared to 15.5 ± 0.9% at 10 pm and 15.5 ± 0.9% at 5 pm (P = 0.04). The physiological state of vasoconstriction after awakening, with preserved capability to dilate in the morning, should be considered to be part of the healthy cardiovascular adaptation before considering later life risk factors and endothelial dysfunction.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Research. Ribeirao Preto,. Vol. 41, no. 6 (jun. 2008), p. 500-503pt_BR
dc.rightsOpen Accessen
dc.subjectCardiovascular risk factoren
dc.subjectVasoconstriçãopt_BR
dc.subjectCircadian rhythmen
dc.subjectBrachial arteryen
dc.subjectVasoconstrictionen
dc.subjectVascular biologyen
dc.titleDiurnal variation of vascular diameter and reactivity in healthy young menpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000704670pt_BR
dc.type.originNacionalpt_BR


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