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Effect of the consumption of tomato paste on plasma prostate-specific antigen levels in patients with benign prostate hyperplasia

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Effect of the consumption of tomato paste on plasma prostate-specific antigen levels in patients with benign prostate hyperplasia

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Título Effect of the consumption of tomato paste on plasma prostate-specific antigen levels in patients with benign prostate hyperplasia
Autor Souza, Magda Edinger de
Koff, Walter Jose
Abstract The consumption of tomatoes and tomato products has been associated with a reduced risk of prostate cancer. We observed a decrease of 10.77% in prostate-specific antigen (PSA) levels in patients with benign prostate hyperplasia who were submitted to daily ingestion of tomato paste. This was an experimental rather than a controlled study with a sample of 43 men ranging in age from 45 to 75 years, all with histological diagnoses of benign prostate hyperplasia and plasma PSA levels of 4-10 ng/mL. All patients received 50 g of tomato paste once a day for 10 consecutive weeks and PSA levels were analyzed before, during and after the consumption of tomato paste. ANOVA for repeated measures was used to compare PSA levels before, during and after the consumption of tomato paste. The mean ± SD PSA level was 6.51 ± 1.48 ng/mL at baseline and 5.81 ± 1.58 ng/mL (P = 0.005) after 10 weeks. Acceptance was good in 88.3, regular in 9.3, and poor in 2.3% of the patients. Dietary ingestion of 50 g of tomato paste per day for 10 weeks significantly reduced mean plasma PSA levels in patients with benign prostate hyperplasia, probably as a result of the high amount of lycopene in tomato paste. This was not a prostate cancer prevention study, but showed some action of tomato paste in prostate biology. The development of prostate cancer is typically accompanied by an increase in plasma PSA levels, thus any intervention that affects plasma PSA levels can suggest an impact in the progression of disease.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 39, n. 8 (ago. 2006), p. 1115-1119
Assunto Antígeno prostático específico
Lycopersicon esculentum
Neoplasias da próstata
[en] Lycopene
[en] Prostate cancer
[en] Prostate-specific antigen
[en] Tomatoes
[en] Tomato paste
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21235
Arquivos Descrição Formato
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