Repositório Digital

A- A A+

In vitro antimicrobial activity of a new series of 1,4-naphthoquinones

.

In vitro antimicrobial activity of a new series of 1,4-naphthoquinones

Mostrar registro completo

Estatísticas

Título In vitro antimicrobial activity of a new series of 1,4-naphthoquinones
Autor Riffel, Alessandro
Medina, Luis Fernando da Costa
Stefani, Valter
Santos, R.C.
Bizani, Delmar
Brandelli, Adriano
Abstract The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino- 8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 μg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3- diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 μg/ml. All compounds presented a minimal bactericidal concentration higher than 500 μg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 μg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy.
Contido em Brazilian journal of medical and biological research =Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 35, no. 7 (jul. 2002), p. 811-818
Assunto Atividade antimicrobiana
Naftoquinonas
[en] 2,3-Diamino-1,4-naphthoquinone
[en] 5-Acetamido-8-hydroxy-1,4-naphthoquinone
[en] Antimicrobial agent
[en] Naphthazarin
[en] Staphylococcus aureus
[en] 5-Amino-8-hydroxy-1,4- naphthoquinone
[en] Quinone
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21273
Arquivos Descrição Formato
000327627.pdf (439.0Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.