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Risk factors for hepatitis C virus infection among blood donors in southern Brazil : a case-control study

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Risk factors for hepatitis C virus infection among blood donors in southern Brazil : a case-control study

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Título Risk factors for hepatitis C virus infection among blood donors in southern Brazil : a case-control study
Autor Brandao, Ajacio Bandeira de Mello
Abstract Background: In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of this case-control study was to investigate the risk factors for presence of anti-HCV antibody in blood donors in southern Brazil. Methods: One hundred and seventy eight blood donors with two positive ELISA results for anti- HCV were cases, and 356 controls tested negative. A standardized questionnaire was used to collect data concerning demographic and socioeconomic aspects, history of previous hepatitis infection, social and sexual behaviors, and number of donations. Variables were grouped into sets of hierarchical categories. Cases and controls were compared using logistic regression, odds ratios, and 95% confidence intervals. The statistical significance of the associations was assessed through likelihood ratio tests based on a P value < 0.05. Results: The prevalence of anti-HCV among blood donors was 1.1%. Most of the donors were white and males. In the multivariate analysis, independent predictors of anti-HCV positivity were: intravenous drug use, blood transfusion >10 years earlier, having had two to four sexually transmitted diseases, incarceration, tattooing, sex with a hepatitis B or C virus carrier or with intravenous drug users. Conclusion: Intravenous drug use, blood transfusion, and tattooing were the main risk factors for anti-HCV positivity among blood donors from southern Brazil, but sexual HCV transmission should also be considered.
Contido em BMC gastroenterology [electronic resource]. London : BioMed Central, [2001-. Vol. 2 (8 Aug. 2002), p. 1-8
Assunto Brasil
Doadores de sangue
Estudos soroepidemiológicos
Hepatite C
[en] Blood donors
[en] Blood transfusion
[en] Hepatitis C
[en] Incarceration
[en] Intravenous drug abuse
[en] Risk factors
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21538
Arquivos Descrição Formato
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