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Weight loss and brown adipose tissue reduction in rat model of sleep apnea

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Weight loss and brown adipose tissue reduction in rat model of sleep apnea

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Título Weight loss and brown adipose tissue reduction in rat model of sleep apnea
Autor Martinez, Denis
Vasconcellos, Luiz Felipe Teer de
Oliveira, Patricia Gnieslaw de
Konrad, Signorá Peres
Abstract Background -: Obesity is related to obstructive sleep apnea-hypopnea syndrome (OSAHS), but its roles in OSAHS as cause or consequence are not fully clarified. Isocapnic intermittent hypoxia (IIH) is a model of OSAHS. We verified the effect of IIH on body weight and brown adipose tissue (BAT) of Wistar rats. Methods: Nine-month-old male breeders Wistar rats of two groups were studied: 8 rats submitted to IIH and 5 control rats submitted to sham IIH. The rats were weighed at the baseline and at the end of three weeks, after being placed in the IIH apparatus seven days per week, eight hours a day, in the lights on period, simulating an apnea index of 30/hour. After experimental period, the animals were weighed and measured as well as the BAT, abdominal, perirenal, and epididymal fat, the heart, and the gastrocnemius muscle. Results: Body weight of the hypoxia group decreased 17 ± 7 grams, significantly different from the variation observed in the control group (p = 0,001). The BAT was 15% lighter in the hypoxia group and reached marginally the alpha error probability (p = 0.054). Conclusion: Our preliminary results justify a larger study for a longer time in order to confirm the effect of isocapnic intermittent hypoxia on body weight and BAT.
Contido em Lipids in health and disease. London. Vol. 7, no. 26 (Jul. 2008), p. 1-5
Assunto Apnéia do sono tipo obstrutiva
Obesidade
Síndromes da apnéia do sono
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21555
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