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Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

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Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

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Título Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
Autor Prolla, Patrícia Ashton
Giacomazzi, Juliana
Schmidt, Aishameriane Venes
Roth, Fernanda Lenara
Palmero, Edenir Inêz
Kalakun, Luciane
Aguiar, Ernestina Silva de
Moreira, Susana Mayer
Batassini, Érica
Belo-Reyes, Vanessa
Faccini, Lavinia Schuler
Giugliani, Roberto
Caleffi, Maira
Camey, Suzi Alves
Abstract Background: Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed to reduce risk, has become increasingly relevant. A previous study in Southern Brazil has shown that a family history suggestive of these syndromes may be prevalent at the primary care level. Development of a simple and sensitive instrument, easily applicable in primary care units, would be particularly helpful in underserved communities in which identification and referral of high-risk individuals is difficult. Methods: A simple 7-question instrument about family history of breast, ovarian and colorectal cancer, FHS-7, was developed to screen for individuals with an increased risk for hereditary breast cancer syndromes. FHS-7 was applied to 9218 women during routine visits to primary care units in Southern Brazil. Two consecutive samples of 885 women and 910 women who answered positively to at least one question and negatively to all questions were included, respectively. The sensitivity, specificity and positive and negative predictive values were determined. Results: Of the 885 women reporting a positive family history, 211 (23.8%; CI95%: 21.5–26.2) had a pedigree suggestive of a hereditary breast and/or breast and colorectal cancer syndrome. Using as cut point one positive answer, the sensitivity and specificity of the instrument were 87.6% and 56.4%, respectively. Concordance between answers in two different applications was given by a intra-class correlation (ICC) of 0.84 for at least one positive answer. Temporal stability of the instrument was adequate (ICC = 0.65). Conclusion: A simple instrument for the identification of the most common hereditary breast cancer syndrome phenotypes, showing good specificity and temporal stability was developed and could be used as a screening tool in primary care to refer at-risk individuals for genetic evaluations.
Contido em BMC Cancer. London. Vol. 9 (Aug. 2009), 9 p.
Assunto Câncer de mama
Doenças genéticas inatas
Estatística aplicada
Neoplasias da mama
Serviço hospitalar de oncologia
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21557
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