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dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.contributor.authorGiacomazzi, Julianapt_BR
dc.contributor.authorSchmidt, Aishameriane Venespt_BR
dc.contributor.authorRoth, Fernanda Lenarapt_BR
dc.contributor.authorPalmero, Edenir Inêzpt_BR
dc.contributor.authorKalakun, Lucianept_BR
dc.contributor.authorAguiar, Ernestina Silva dept_BR
dc.contributor.authorMoreira, Susana Mayerpt_BR
dc.contributor.authorBatassini, Éricapt_BR
dc.contributor.authorBelo-Reyes, Vanessapt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorGiugliani, Robertopt_BR
dc.contributor.authorCaleffi, Mairapt_BR
dc.contributor.authorCamey, Suzi Alvespt_BR
dc.date.accessioned2010-05-05T04:15:55Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn1471-2407pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21557pt_BR
dc.description.abstractBackground: Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed to reduce risk, has become increasingly relevant. A previous study in Southern Brazil has shown that a family history suggestive of these syndromes may be prevalent at the primary care level. Development of a simple and sensitive instrument, easily applicable in primary care units, would be particularly helpful in underserved communities in which identification and referral of high-risk individuals is difficult. Methods: A simple 7-question instrument about family history of breast, ovarian and colorectal cancer, FHS-7, was developed to screen for individuals with an increased risk for hereditary breast cancer syndromes. FHS-7 was applied to 9218 women during routine visits to primary care units in Southern Brazil. Two consecutive samples of 885 women and 910 women who answered positively to at least one question and negatively to all questions were included, respectively. The sensitivity, specificity and positive and negative predictive values were determined. Results: Of the 885 women reporting a positive family history, 211 (23.8%; CI95%: 21.5–26.2) had a pedigree suggestive of a hereditary breast and/or breast and colorectal cancer syndrome. Using as cut point one positive answer, the sensitivity and specificity of the instrument were 87.6% and 56.4%, respectively. Concordance between answers in two different applications was given by a intra-class correlation (ICC) of 0.84 for at least one positive answer. Temporal stability of the instrument was adequate (ICC = 0.65). Conclusion: A simple instrument for the identification of the most common hereditary breast cancer syndrome phenotypes, showing good specificity and temporal stability was developed and could be used as a screening tool in primary care to refer at-risk individuals for genetic evaluations.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBMC Cancer. London. Vol. 9 (Aug. 2009), 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEstatística aplicadapt_BR
dc.subjectNeoplasias da mamapt_BR
dc.subjectDoenças genéticas inataspt_BR
dc.titleDevelopment and validation of a simple questionnaire for the identification of hereditary breast cancer in primary carept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000715066pt_BR
dc.type.originEstrangeiropt_BR


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