Repositório Digital

A- A A+

Transcriptome analysis of Taenia solium cysticerci using Open Reading Frama ESTs (ORESTES)

.

Transcriptome analysis of Taenia solium cysticerci using Open Reading Frama ESTs (ORESTES)

Mostrar registro completo

Estatísticas

Título Transcriptome analysis of Taenia solium cysticerci using Open Reading Frama ESTs (ORESTES)
Autor Almeida, Carolina R.
Stoco, Patricia Hermes
Wagner, Glauber
Sincero, Thaís Cristine Marques
Rotava, Gianinna
Bayer-Santos, Ethel
Rodrigues, Juliana B.
Sperandio, Maísa M.
Maia, Antônio A. M.
Ojopi, Elida P. B.
Zaha, Arnaldo
Ferreira, Henrique Bunselmeyer
Tyler, Kevin M.
Dávila, Alberto M. R.
Grisard, Edmundo Carlos
Dias Neto, Emmanuel
Abstract Background: Human infection by the pork tapeworm Taenia solium affects more than 50 million people worldwide, particularly in underdeveloped and developing countries. Cysticercosis which arises from larval encystation can be life threatening and difficult to treat. Here, we investigate for the first time the transcriptome of the clinically relevant cysticerci larval form. Results: Using Expressed Sequence Tags (ESTs) produced by the ORESTES method, a total of 1,520 high quality ESTs were generated from 20 ORESTES cDNA mini-libraries and its analysis revealed fragments of genes with promising applications including 51 ESTs matching antigens previously described in other species, as well as 113 sequences representing proteins with potential extracellular localization, with obvious applications for immune-diagnosis or vaccine development. Conclusion: The set of sequences described here will contribute to deciphering the expression profile of this important parasite and will be informative for the genome assembly and annotation, as well as for studies of intra- and inter-specific sequence variability. Genes of interest for developing new diagnostic and therapeutic tools are described and discussed.
Contido em Parasites & Vectors. London : BioMed Central, 2008-. Vol. 2, no. 35 (Jul. 2009), p. 1-11.
Assunto Cisticercose
Open reading frame ESTs
Taenia ssp
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21558
Arquivos Descrição Formato
000716697.pdf (1.198Mb) Texto completo Adobe PDF Visualizar/abrir
000716697.zip (430.5Kb) Material suplementar Arquivo ZIP Visualizar/abrir
000716697-02.zip (1.005Mb) Trabalho completo zipado Arquivo ZIP Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.