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Maternal consumption of polyphenol rich foods in late pregnancy and fetal ductus arteriosus flow dynamics

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Maternal consumption of polyphenol rich foods in late pregnancy and fetal ductus arteriosus flow dynamics

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Título Maternal consumption of polyphenol rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
Autor Zielinsky, Paulo
Piccoli Junior, Antônio Luiz
Manica, João Luiz
Nicoloso, Luis Henrique
Menezes, Herli Joaquim de
Busato, André Krieger
Moraes, M.
Silva, J.
Bender, I.B.
Pizzato, Patricia
Aita, Leonardo
Alievi, Marcelo Meller
Vian, Itamar Navildo
Almeida, L.
Abstract Objective: To test the hypothesis that maternal consumption of polyphenol-rich foods during third trimester interferes with fetal ductal dynamics by inhibition of prostaglandin synthesis. Study Design: In a prospective analysis, Doppler ductal velocities and right-to-left ventricular dimensions ratio of 102 fetuses exposed to polyphenol-rich foods (daily estimated maternal consumption >75th percentile, or 1089 mg) were compared with 41 unexposed fetuses (flavonoid ingestion <25th percentile, or 127 mg). Result: In the exposed fetuses, ductal velocities were higher (systolic: 0.96±0.23 m/s; diastolic: 0.17±0.05 m/s) and right-to-left ventricular ratio was higher (1.23±0.23) than in unexposed fetuses (systolic: 0.61±0.18 m/s, P<0.001; diastolic: 0.11±0.04 m/s, P¼0.011; right-toleft ventricular ratio: 0.94±0.14, P<0.001). Conclusion: As maternal polyphenol-rich foods intake in late gestation may trigger alterations in fetal ductal dynamics, changes in perinatal dietary orientation are warranted.
Contido em Journal of perinatology. Journal of Perinatology. England, NPG, 2010. V.30, n.1(jan. 2010), p. 17-21
Assunto Clinica veterinaria
Ecocardiografia fetal
[en] Ductus arteriosus
[en] Echocardiography
[en] Prostaglandins
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21685
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