Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
dc.contributor.author | Marschner, Rafael Aguiar | pt_BR |
dc.contributor.author | Banda, Patrícia Da Silva | pt_BR |
dc.contributor.author | Wajner, Simone Magagnin | pt_BR |
dc.contributor.author | Markoski, Melissa Medeiros | pt_BR |
dc.contributor.author | Schaun, Maximiliano Isoppo | pt_BR |
dc.contributor.author | Lehnen, Alexandre Machado | pt_BR |
dc.date.accessioned | 2021-05-13T04:25:07Z | pt_BR |
dc.date.issued | 2019 | pt_BR |
dc.identifier.issn | 1932-6203 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/220765 | pt_BR |
dc.description.abstract | Aims: We assessed the effects of a short-term exercise training on cardiac function, oxidative stress markers, and type 3 iodothyronine deiodinase (D3) activity in cardiac tissue of spontaneously hypertensive rats (SHR) following experimental myocardial infarction (MI). Methods: Twenty-four SHR (aged 3 months) were allocated to 4 groups: sham+sedentary, sham+trained, MI+sedentary and MI+trained. MI was performed by permanent ligation of the coronary artery. Exercise training (treadmill) started 96 hours after MI and lasted for 4 weeks (~60% maximum effort, 4x/week and 40 min/day). Cardiac function (echocardiography), thioredoxin reductase (TRx), total carbonyl levels, among other oxidative stress markers and D3 activity were measured. A Generalized Estimating Equation was used, followed by Bonferroni’s test (p<0.05). Results: MI resulted in an increase in left ventricular mass (p = 0.002) with decreased cardiac output (~22.0%, p = 0.047) and decreased ejection fraction (~41%, p = 0.008) as well as an increase in the carbonyl levels (p = 0.001) and D3 activity (~33%, p<0.001). Exercise training resulted in a decrease in left ventricular mass, restored cardiac output (~34%, p = 0.048) and ejection fraction (~20%, p = 0.040), increased TRx (~85%, p = 0.007) and reduced carbonyl levels (p<0.001) and D3 activity (p<0.001). Conclusions: Our short-term exercise training helped reverse the effects of MI on cardiac function. These benefits seem to derive from a more efficient antioxidant response and lower D3 activity in cardiac tissue. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | PloS one. San Francisco. Vol. 14, no. 9 (Sept. 2019), e0222334, 15 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Exercício | pt_BR |
dc.subject | Myocardial infarction | en |
dc.subject | Exercise | en |
dc.subject | Infarto do miocárdio | pt_BR |
dc.subject | Cardiovascular physiology | en |
dc.subject | Antioxidantes | pt_BR |
dc.subject | Antioxidants | en |
dc.subject | Oxidation-reduction reactions | en |
dc.subject | Sedentary behavior | en |
dc.subject | Glutathione | en |
dc.subject | Oxidative stress | en |
dc.title | Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001122970 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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