Dualities of the vitamin D in systemic sclerosis : a systematic literature review
dc.contributor.author | Schneider, Laiana | pt_BR |
dc.contributor.author | Hax, Vanessa | pt_BR |
dc.contributor.author | Monticielo, Odirlei André | pt_BR |
dc.contributor.author | Macedo, Tamires Ferri | pt_BR |
dc.contributor.author | Menna Barreto, Roberta Kern | pt_BR |
dc.contributor.author | Marcondes, Natália Aydos | pt_BR |
dc.contributor.author | Chakr, Rafael Mendonça da Silva | pt_BR |
dc.date.accessioned | 2021-09-01T04:24:12Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2523-3106 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/229306 | pt_BR |
dc.description.abstract | Background: Systemic sclerosis (SSc) is a chronic disease characterized by autoimmunity, vasculopathy, and visceral and cutaneous fibrosis. Vitamin D has several functions in the immunological system, and different studies have suggested a potential role in triggering autoimmune diseases. Patients with SSc may present with low serum levels of vitamin D, but the association between hypovitaminosis D and disease onset or any clinical manifestation is still obscure. Our goal was to verify the causal relationship between hypovitaminosis D and SSc onset or any particular clinical manifestation in the literature. Methods: A systematic literature review was performed through February 24th, 2021 on Pubmed, Lilacs/BIREME, and Cochrane databases. The eligible studies were read in full text, and, in the absence of exclusion criteria, were included in this review after consensus between two reviewers. Results: Forty articles met the eligibility criteria and the main results of each study are described. In most studies, SSc patients showed a higher prevalence of vitamin D deficiency and insufficiency compared to controls. Additionally, in some reports serum levels of vitamin D were inversely correlated with the severity of SSc. Oral supplementation did not seem to affect serum levels of vitamin D. Four of the included studies were with experimental models. Conclusion: In conclusion, vitamin D deficiency seems to have a role in susceptibility to SSc, as well as in the clinical manifestations of the disease. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Advances in rheumatology. São Paulo. Vol. 61 (2021), 34, 10 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Escleroderma sistêmico | pt_BR |
dc.subject | Vitamin D | en |
dc.subject | Vitamina D | pt_BR |
dc.subject | Systemic sclerosis | en |
dc.subject | 25-hydroxyvitamin D | en |
dc.subject | Deficiência de vitamina D | pt_BR |
dc.subject | Deficiency | en |
dc.title | Dualities of the vitamin D in systemic sclerosis : a systematic literature review | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001130272 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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