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dc.contributor.authorMentz, Marcia Bohrerpt_BR
dc.contributor.authorTeixeira, Carlos Graeffpt_BR
dc.contributor.authorGarrido, Cinara Tentardinipt_BR
dc.date.accessioned2010-06-01T04:17:57Zpt_BR
dc.date.issued2004pt_BR
dc.identifier.issn0036-4665pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/23154pt_BR
dc.description.abstractAbdominal angiostrongyliasis is a zoonotic infection produced by a metastrongylid intra-arterial nematode, Angiostrongylus costaricensis. Human accidental infection may result in abdominal lesions and treatment with anti-helminthics is contra-indicated because of potential higher morbidity with excitement or death of worms inside vessels. To evaluate the effect of mebendazole on localization of the worms, male Swiss mice, 5 week-old, were infected with 10 third stage larvae per animal. Twelve infected mice were treated with oral mebendazol, at 5 mg/kg/day, for 5 consecutive days, begining 22 days after inoculation. As control groups, 12 infected but non-treated mice and other 12 non-infected and non-treated mice were studied. The findings at necropsy were, respectively for the treated (T) and control (C) groups: 92% and 80% of the worms were inside the cecal mesenteric arterial branch; 8% and 10% were located inside the aorta. Only in the group C some worms (10%) were found inside the portal vein or splenic artery. These data indicate that treatment with mebendazole does not lead to distal or ectopic migration of A. costaricensis worms.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo = Journal of the São Paulo Institute of Tropical Medicine. São Paulo, SP. Vol. 46, n. 2 (2004), p. 73-75pt_BR
dc.rightsOpen Accessen
dc.subjectAngiostrongylus costaricencisen
dc.subjectParasitologiapt_BR
dc.subjectAdult stageen
dc.subjectMigrationen
dc.subjectMebendazoleen
dc.titleTreatment with mebendazole is not associated with distal migration of adult Angiostrongylus costaricensis in the murine experimental infectionpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000468874pt_BR
dc.type.originNacionalpt_BR


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